Study on Diagnostic Markers of Liver Disease in Non Alcoholic and Alcoholic Patients
Habbu PP, Deshmukh V, Shaikh AK
Aims: To evaluate the diagnostic markers of liver disease in alcoholic and non alcoholic patients.
Methodology: The study group included 100 cases among which 50 alcoholic liver disease and 50 with non alcoholic liver disease while control group included 50 healthy persons. Serum urea, creatinine, total bilirubin, total protein, A/G ratio, serum enzyme activity like AST, ALT, ALP, gamma GT, AST/ALT ratio estimation was done by using kit on mini VIDAS.
Results: In present study, patients with liver disease either due to alcohol or without alcohol were compared with a group of normal healthy persons. Mean value of urea, creatinine, total bilirubin, total protein, A/G ratio and enzymatic parameters were determined. The drinker alcoholic liver disease patients had significantly high urea, creatinine and total bilirubin and significantly lower total protein and A/G ratio compared to other groups. The serum enzyme activity like AST, ALT, ALP, γGT, and AST/ALT ratio were found to be significantly increased in comparison to healthy controls as well as in drinkers in comparison to non drinkers. The AST/ALT ratio, γGT and total bilirubin in non alcoholic liver disease correlated with AST/ALT ratio, γGT and total bilirubin in alcoholic liver disease which was negatively correlated with each other.
Conclusion: Hyperbilirubinemia, hyperurea, hypercreatinine, hypoalbuminemia are common features of alcoholics as well as non alcoholic liver disease. Monitoring γGT, ALP, AST and ALT in combination is a sensitive means of detecting severity of liver damage.