Study on Cystatin C An early biomarker for Nephropathy in Type II Diabetic subjects

Mr Pandey KK, Dr Singh N, Dr Raizada A

Type 2 diabetes has become the most common metabolic disorder in India and is a growing problem with over 40 million diabetic subjects. The Asian Indian phenotype is associated with increased insulin resistance, greater abdominal adiposity despite lower body mass index, lower adiponectin and higher high sensitivity C - reactive protein levels makes Asians more prone to diabetes. Among Indians, the onset of type 2 diabetes occurs at a younger age and hence, they are vulnerable to all the complications of diabetes due to longer duration of the disease. An overnight fasting blood sample was collected from both cases and controls and the samples were centrifuged and separated for the estimations. Estimations of fasting blood glucose, blood urea and serum creatine were performed. Estimation of serum cystatin C was done by immunoturbidimetric method. The care of patients with diabetes and end stage renal disease contributes significantly to health care costs. In the past couple of decades, there have been notable advances in our knowledge regarding the early stages of diabetic kidney disease, including the advent of interventions that can significantly slow or even reverse the progression of disease. The limitations of currently available parameters in early detection of renal dysfunction have prompted a search for newer, more reliable markers of renal function. This study attempts to determine the utility of serum Cystatin C in predicting early decline in renal function so that appropriate and timely interventions can be instituted to delay or arrest the progression of diabetic nephropathy.

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