Prenatal hepatic changes induced by Lamivudine in Swiss albino mice

Dr Sunhare N, Dr Mishra A

Aims and Objectives: Lamivudine is a reverse transcriptase inhibitor used in pregnant females infected with hepatitis B or HIV virus to prevent maternal to child transmission. The present study is aimed to observe the toxic effects of Lamivudine on liver in growing embryo. Material and Methods: Lamivudine was given to pregnant Swiss Albino mice by oral gavage in doses of 18mg/kg b.w and 30mg/kg b.w from 6-15th day of gestation. The control mice were fed distilled water by the same route on the same gestational days. The pregnant mice were sacrificed on 18th day of gestation by cervical dislocation and livers were dissected out from the foetuses, observed for any gross malformation and then processed for histological study. Result: In the gross examination of liver, there was a reduction in size and presence of haemmorhagic patches on the liver. On histological examination, the treated liver was found to show degeneration of hepatoblasts, resulting in large vacuolar spaces, and damaged sinusoids.

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