Morphology and Histogenesis of developing human liver


Abstract: Background: Hepatic tissue made from stem cells holds the promise of an unlimited source of material for transplantation. Liver is one of the organs working without a resting phase. Understanding the molecular mechanism governing liver development will also be valuable for efforts to differentiate therapeutically useful hepatic tissue from stem cells. Aim of study: To correlate body weight, liver weight, crown-rump length with gestational ages and to study microscopic structure of liver at various gestational age groups. Materials and method: Forty human fetuses (19 males and 21 females) of different gestational ages ranging from 12th to 36th gestational weeks were procured for the research work. Result: High correlation between body weight and gestational age of fetus. The Crown-rump length (CRL) showed gradual increase from 12th to 36th weeks of gestation. Highly significant correlation found between liver weight and gestational age of fetus. The percentage relative weight was variable throughout the period of the gestation. Microscopy shows haemopoiesis was abundant at early stages of gestation and decrease as the age of liver advances from 12th to 36th week of gestation. Connective tissue elements increase from 12th week onwards showing thick capsule and thickened trabeculae. Central vein appears at around 16th to 17th weeks of gestation. Branches of portal vein, hepatic artery and bile ductile appear later during development at about 18th week of gestation. Conclusion: All physical parameters showed gradual increase from 12th week to 36th week of gestation. The haemopoietic tissue was found abundant in early stage. Central vein, portal tracts appeared at around 15th to 18th weeks of gestation.

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