Morphology and Histogenesis of developing human liver
DR. HASHMI INTKHAB C, DR. WANKHEDE HARISH A.
Background: Hepatic tissue made from stem cells holds the promise of an
unlimited source of material for transplantation. Liver is one of the organs
working without a resting phase. Understanding the molecular mechanism
governing liver development will also be valuable for efforts to
differentiate therapeutically useful hepatic tissue from stem cells.
Aim of study: To correlate body weight, liver weight, crown-rump length
with gestational ages and to study microscopic structure of liver at various
gestational age groups.
Materials and method: Forty human fetuses (19 males and 21 females) of
different gestational ages ranging from 12th to 36th gestational weeks were
procured for the research work.
Result: High correlation between body weight and gestational age of fetus.
The Crown-rump length (CRL) showed gradual increase from 12th to 36th
weeks of gestation. Highly significant correlation found between liver
weight and gestational age of fetus. The percentage relative weight was
variable throughout the period of the gestation. Microscopy shows
haemopoiesis was abundant at early stages of gestation and decrease as the
age of liver advances from 12th to 36th week of gestation. Connective tissue
elements increase from 12th week onwards showing thick capsule and
thickened trabeculae. Central vein appears at around 16th to 17th weeks of
gestation. Branches of portal vein, hepatic artery and bile ductile appear
later during development at about 18th week of gestation.
Conclusion: All physical parameters showed gradual increase from 12th
week to 36th week of gestation. The haemopoietic tissue was found
abundant in early stage. Central vein, portal tracts appeared at around 15th
to 18th weeks of gestation.