Assessment of Sensitivity of Renal Function Tests in Diagnosis of Chronic Renal Failure

Gaikwad Kapila B, Joshi Nitin G

Background: The symptoms of worsening kidney function are unspecific. Laboratory evaluation may be only way of detecting disease. Laboratory tests should detect abnormalities early enough for diagnosis and treatment modalities. Aims & Objectives: To assess sensitivity of various Renal Function Tests in diagnosis of CRF. Materials & Methods: CRF patients of age more than 20 years were included. Four RFTs Sr. creatinine, Blood urea, Sr. uric acid and GFR were estimated. Results & Observations: As compared to control, in CRF urea value is increased by 5.3%, creatinine by 6.9%, uric acid by 2%, GFR decreased by 14%. At a particular degree of kidney damage the deviation in Sr. uric acid is negligible. For urea, the deviation is large; but is influenced by factors like diet. The deviation in creatinine is large. However, the values are numerically small & error tolerance is small. Also age and sex are never considered in expressing Sr.creatinine. The deviation in GFR is largest; the values are numerically high and have more error tolerance. In GFR, age and sex are considered. Conclusion: GFR is more accurate and sensitive index of kidney damage and should be the test of choice.

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