A study on serum uric acids level as prognostic indicator in acute myocardial infarction

Pendkar PG, Shinde A, Manoorkar GS

Coronary heart disease (CHD) is worldwide health epidemic. Although age- specific events related to CHD have fallen dramatically in last few decades, overall prevalence has risen as population age & patients survive the initial coronary/cardiovascular events. We undertook this study to note level of serum uric acid in acute myocardial infarction (MI). Study was done in Dr. S. C. Govt. Medical College & Hospital, Nanded. Study includes 50 patients of acute MI and other 50 age and sex matched control. Serum uric acid level was estimated by uricase method on day 0, 3, 5 in the above patients. On day of admission mean serum uric acid was 7.3 in acute MI patients & in control it was 5.9. There was a statistically significant higher level of serum uric acid concentration in patients of acute MI on the day of admission as compared to control. Mean serum uric acid on day of admission, 3 day, and 5 day was 7.3, 5.6, and 4.5 respectively. Two patients who died after 3 days of hospital stay had serum uric acid level more 7 mg/dl. Serum uric acid levels are higher in patients with acute MI, it is good predictor of mortality after acute MI. Hyperuricemia is indicator of poor prognosis in acute MI.

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